biostudies-literatureOng YHMinistry of EducationDeutsche Forschungsgemeinschaft1145-1153https://www.ebi.ac.uk/biostudies/studies/S-EPMC5575487biostudies-literatureUnknown34(8)<h4>Aim</h4>To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population.<h4>Methods</h4>For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20-60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols.<h4>Results</h4>The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1-16.0; P<0.001) in the white European cohort compared with 6.8% (95% CI 5.5-8.4; P<0.001) in the Asian cohort. Glutamic acid decarboxylase antibody positivity was 11.4% (95% CI 7.7-16.6) in Indian, 6.0% (95% CI 3.6-9.9) in MaDiabetic medicine : a journal of the British Diabetic AssociationGlutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany.PMC5575487GrK1041SFB518RG 1T1‐10/15Boehm JLippmann-Grob BHaenle MKratzer WDalan RSeufferlein TClaudi-Boehm STai ESManfras BJutting GBee YMLee ESToh MPBoehm BOHaak TBruckel JSchilling SLeow MKRosinger SKoh WCASrinivasan DKChia KSHopfer STrischler GLim SCKurkhaus AOng YHChew DEKSim XTan WEAli YKhoo CMTavintharan SNg MLBlagieva RKleger ASing RAdult-Onset Autoimmune Diabetes Mellitus Consortium (ADAMS)Sum CFMerger SNg SPTam ZYfalseGlutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany.<h4>Aim</h4>To gain insight into the presence of islet cell autoimmunity in an ethnic Asian compared with a white European population.<h4>Methods</h4>For this cross-sectional study we recruited people with adult-onset diabetes (age of diagnosis 20-60 years), at tertiary referral centres in Germany (n=1020) and Singapore (n=1088). Glutamic acid decarboxylase and islet antigen 2 antibodies were measured according to Islet Autoantibody Standardization Program protocols.<h4>Results</h4>The prevalence of glutamic acid decarboxylase antibody positivity was 13.9% (95% CI 12.1-16.0; P<0.001) in the white European cohort compared with 6.8% (95% CI 5.5-8.4; P<0.001) in the Asian cohort. Glutamic acid decarboxylase antibody positivity was 11.4% (95% CI 7.7-16.6) in Indian, 6.0% (95% CI 3.6-9.9) in Ma2017-01-01T00:00:00Z2017 Aug2026-05-05T22:14:23.639Z2019-03-27T02:54:49ZS-EPMC55754872837032910.1111/dme.13358