{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":53,"searchCount":0},"additional":{"submitter":["Okely JA"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["742-748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5576535"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(7)"],"pubmed_abstract":["<h4>Objective</h4>Higher levels of well-being are associated with lower levels of inflammatory markers in healthy populations; however, it is unclear whether this association translates into a reduced risk of disease. In the current study, we tested whether the association between well-being and inflammation results in a lower risk of arthritis.<h4>Methods</h4>The sample consisted of 5266 participants 50 years or older from the English Longitudinal Study of Ageing and included six waves of data collection. We used a structural equation modeling approach to test whether inflammatory markers (C-reactive protein [CRP] or fibrinogen) mediated the association between well-being and arthritis risk for a 10-year follow-up period.<h4>Results</h4>Higher levels of well-being were associated with a decrease in arthritis risk (hazard ratio = 0.97 per unit, 95% confidence interval = 0.96 to 0.98, p < .001). Of the two inflammatory markers, only CRP was associated with arthritis risk. Mediation analysis revealed that the indirect effect of well-being (at wave 1) on arthritis risk via CRP (at wave 2) was significant (hazard ratio = 0.996, 95% confidence interval = 0.995 to 0.998, p < .001). This effect remained significant after adjustment for demographic and health behavior variables and depressive symptoms.<h4>Conclusions</h4>CRP accounts for a small proportion of the association between well-being and a reduced risk of arthritis."],"journal":["Psychosomatic medicine"],"pubmed_title":["Well-Being and Arthritis Incidence: The Role of Inflammatory Mechanisms. Findings From the English Longitudinal Study of Ageing."],"pmcid":["PMC5576535"],"funding_grant_id":["NF-SI-0508-10082","MC_U147585819","MC_UP_A620_1014","MC_UU_12011/2","G0400491","MC_UU_12011/1","U1475000001","MC_U147585824","NF-SI-0513-10085","MC_U147585827","MR/K026992/1","1578662"],"pubmed_authors":["Weiss A","Okely JA","Gale CR"],"view_count":["53"],"additional_accession":[]},"is_claimable":false,"name":"Well-Being and Arthritis Incidence: The Role of Inflammatory Mechanisms. Findings From the English Longitudinal Study of Ageing.","description":"<h4>Objective</h4>Higher levels of well-being are associated with lower levels of inflammatory markers in healthy populations; however, it is unclear whether this association translates into a reduced risk of disease. In the current study, we tested whether the association between well-being and inflammation results in a lower risk of arthritis.<h4>Methods</h4>The sample consisted of 5266 participants 50 years or older from the English Longitudinal Study of Ageing and included six waves of data collection. We used a structural equation modeling approach to test whether inflammatory markers (C-reactive protein [CRP] or fibrinogen) mediated the association between well-being and arthritis risk for a 10-year follow-up period.<h4>Results</h4>Higher levels of well-being were associated with a decrease in arthritis risk (hazard ratio = 0.97 per unit, 95% confidence interval = 0.96 to 0.98, p < .001). Of the two inflammatory markers, only CRP was associated with arthritis risk. Mediation analysis revealed that the indirect effect of well-being (at wave 1) on arthritis risk via CRP (at wave 2) was significant (hazard ratio = 0.996, 95% confidence interval = 0.995 to 0.998, p < .001). This effect remained significant after adjustment for demographic and health behavior variables and depressive symptoms.<h4>Conclusions</h4>CRP accounts for a small proportion of the association between well-being and a reduced risk of arthritis.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2024-02-15T06:35:33.071Z","creation":"2019-03-27T02:54:53Z"},"accession":"S-EPMC5576535","cross_references":{"pubmed":["28604559"],"doi":["10.1097/PSY.0000000000000480"]}}