{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krol E"],"funding":["Ministry of Science and Higher Education, Poland"],"pagination":["E1700"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5578090"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(8)"],"pubmed_abstract":["Influenza virus infection is a major cause of morbidity and mortality worldwide. Due to the limited ability of currently available treatments, there is an urgent need for new anti-influenza drugs with broad spectrum protection. We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy. In this study, a number of IW3 and IW7 analogues with different structural modifications in 2-deoxy sugar or uridine parts were synthesized and evaluated for their ability to inhibit influenza A virus infection in vitro. Using the cytopathic effect (CPE) inhibit"],"journal":["International journal of molecular sciences"],"pubmed_title":["Biological Evaluation of Uridine Derivatives of 2-Deoxy Sugars as Potential Antiviral Compounds against Influenza A Virus."],"pmcid":["PMC5578090"],"funding_grant_id":["IP2011 027271"],"pubmed_authors":["Krejmer-Rabalska M","Wandzik I","Krol E","Szewczyk B"],"additional_accession":[]},"is_claimable":false,"name":"Biological Evaluation of Uridine Derivatives of 2-Deoxy Sugars as Potential Antiviral Compounds against Influenza A Virus.","description":"Influenza virus infection is a major cause of morbidity and mortality worldwide. Due to the limited ability of currently available treatments, there is an urgent need for new anti-influenza drugs with broad spectrum protection. We have previously shown that two 2-deoxy sugar derivatives of uridine (designated IW3 and IW7) targeting the glycan processing steps during maturation of viral glycoproteins show good anti-influenza virus activity and may be a promising alternative approach for the development of new anti-influenza therapy. In this study, a number of IW3 and IW7 analogues with different structural modifications in 2-deoxy sugar or uridine parts were synthesized and evaluated for their ability to inhibit influenza A virus infection in vitro. Using the cytopathic effect (CPE) inhibit","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-07-15T18:30:29.542Z","creation":"2019-03-27T02:55:01Z"},"accession":"S-EPMC5578090","cross_references":{"pubmed":["28777309"],"doi":["10.3390/ijms18081700"]}}