{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moreau P"],"funding":["NCI NIH HHS"],"pagination":["2911-2918"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5578392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(25)"],"pubmed_abstract":["Purpose Magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) are important imaging techniques in multiple myeloma (MM). We conducted a prospective trial in patients with MM aimed at comparing MRI and PET-CT with respect to the detection of bone lesions at diagnosis and the prognostic value of the techniques. Patients and Methods One hundred thirty-four patients received a combination of lenalidomide, bortezomib, and dexamethasone (RVD) with or without autologous stem-cell transplantation, followed by lenalidomide maintenance. PET-CT and MRI were performed at diagnosis, after three cycles of RVD, and before maintenance therapy. The primary end point was the detection of bone lesions at diagnosis by MRI versus PET-CT. Secondary end points included th"],"journal":["Journal of clinical oncology : official journal of the American Society of Clinical Oncology"],"pubmed_title":["Prospective Evaluation of Magnetic Resonance Imaging and [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study."],"pmcid":["PMC5578392"],"funding_grant_id":["P01 CA155258"],"pubmed_authors":["Moreau P","Munshi NC","Gaultier A","Nguyen JM","Dupas B","Stoppa AM","Facon T","Eveillard JR","Chaleteix C","Kraeber-Bodere F","Karlin L","Garderet L","Pegourie B","Richardson P","Caillon F","Dorvaux V","Benboubker L","Laribi K","Hulin C","Perrot A","Marit G","Attal M","Caillot D","Anderson K","Bodet-Milin C","Macro M","Avet-Loiseau H","Frampas E","Escoffre-Barbe M"],"additional_accession":[]},"is_claimable":false,"name":"Prospective Evaluation of Magnetic Resonance Imaging and [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.","description":"Purpose Magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) are important imaging techniques in multiple myeloma (MM). We conducted a prospective trial in patients with MM aimed at comparing MRI and PET-CT with respect to the detection of bone lesions at diagnosis and the prognostic value of the techniques. Patients and Methods One hundred thirty-four patients received a combination of lenalidomide, bortezomib, and dexamethasone (RVD) with or without autologous stem-cell transplantation, followed by lenalidomide maintenance. PET-CT and MRI were performed at diagnosis, after three cycles of RVD, and before maintenance therapy. The primary end point was the detection of bone lesions at diagnosis by MRI versus PET-CT. Secondary end points included th","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-05-29T21:08:11.143Z","creation":"2019-03-26T23:53:50Z"},"accession":"S-EPMC5578392","cross_references":{"pubmed":["28686535"],"doi":["10.1200/JCO.2017.72.2975","10.1200/jco.2017.72.2975"]}}