{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shockley SE"],"funding":["NIGMS NIH HHS"],"pagination":["3341-3343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5578629"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(34)"],"pubmed_abstract":["Rapid access to enantioenriched spirocycles possessing a 1,4-dicarbonyl moiety spanning an all-carbon quaternary stereogenic spirocenter was achieved using a masked bromomethyl vinyl ketone reagent. The developed protocol entails an enantioselective palladium-catalyzed allylic alkylation reaction followed by a one-pot unmasking/RCM sequence that provides access to the spirocyclic compounds in good yields and selectivities."],"journal":["Tetrahedron letters"],"pubmed_title":["Asymmetric Synthesis of All-Carbon Quaternary Spirocycles via a Catalytic Enantioselective Allylic Alkylation Strategy."],"pmcid":["PMC5578629"],"funding_grant_id":["R01 GM080269"],"pubmed_authors":["Hethcox JC","Stoltz BM","Shockley SE"],"additional_accession":[]},"is_claimable":false,"name":"Asymmetric Synthesis of All-Carbon Quaternary Spirocycles via a Catalytic Enantioselective Allylic Alkylation Strategy.","description":"Rapid access to enantioenriched spirocycles possessing a 1,4-dicarbonyl moiety spanning an all-carbon quaternary stereogenic spirocenter was achieved using a masked bromomethyl vinyl ketone reagent. The developed protocol entails an enantioselective palladium-catalyzed allylic alkylation reaction followed by a one-pot unmasking/RCM sequence that provides access to the spirocyclic compounds in good yields and selectivities.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-26T11:15:28.143Z","creation":"2019-03-26T23:51:57Z"},"accession":"S-EPMC5578629","cross_references":{"pubmed":["28867835"],"doi":["10.1016/j.tetlet.2017.07.022"]}}