biostudies-literatureShockley SENIGMS NIH HHS3341-3343https://www.ebi.ac.uk/biostudies/studies/S-EPMC5578629biostudies-literatureUnknown58(34)Rapid access to enantioenriched spirocycles possessing a 1,4-dicarbonyl moiety spanning an all-carbon quaternary stereogenic spirocenter was achieved using a masked bromomethyl vinyl ketone reagent. The developed protocol entails an enantioselective palladium-catalyzed allylic alkylation reaction followed by a one-pot unmasking/RCM sequence that provides access to the spirocyclic compounds in good yields and selectivities.Tetrahedron lettersAsymmetric Synthesis of All-Carbon Quaternary Spirocycles via a Catalytic Enantioselective Allylic Alkylation Strategy.PMC5578629R01 GM080269Hethcox JCStoltz BMShockley SEfalseAsymmetric Synthesis of All-Carbon Quaternary Spirocycles via a Catalytic Enantioselective Allylic Alkylation Strategy.Rapid access to enantioenriched spirocycles possessing a 1,4-dicarbonyl moiety spanning an all-carbon quaternary stereogenic spirocenter was achieved using a masked bromomethyl vinyl ketone reagent. The developed protocol entails an enantioselective palladium-catalyzed allylic alkylation reaction followed by a one-pot unmasking/RCM sequence that provides access to the spirocyclic compounds in good yields and selectivities.2017-01-01T00:00:00Z2017 Aug2025-04-26T11:15:28.143Z2019-03-26T23:51:57ZS-EPMC55786292886783510.1016/j.tetlet.2017.07.022