biostudies-literatureUnknown1(1)Dunkel JEmil Aaltonen Foundation, Ida Montin Foundation, Kirsti and Tor Johansson Foundation, University of Turku, and Turku University Hospital<h4>Objectives/hypothesis</h4>No biomarkers are used to estimate the prognosis in oral cavity squamous cell carcinoma (OSCC). In our previously published work, we have reported the prognostic value of CD44 and hypoxia inducible factor (HIF)-1α in patients with stage I disease.<h4>Study design</h4>In this study, we tested our previous observations in a larger cohort. We also studied the predictive value of common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 in this material.<h4>Methods</h4>CD44, HIF1α, and CLEVER-1 were immunohistochemically analyzed in paraffin-embedded tissue material of stage I OSCC patients treated at three Finnish university hospitals. Microscopy results were correlated with OSCC outcome.<h4>Results</h4>As in our pilot study, the CD44<sup>low</supLaryngoscope investigative otolaryngology6-12https://www.ebi.ac.uk/biostudies/studies/S-EPMC5580857biostudies-literatureTumoral Expression of CD44 and HIF1α Predict Stage I Oral Cavity Squamous Cell Carcinoma Outcome.PMC5580857Vaittinen SMakinen MJTommola SLaranne JIrjala HKoivunen PDunkel JfalseTumoral Expression of CD44 and HIF1α Predict Stage I Oral Cavity Squamous Cell Carcinoma Outcome.<h4>Objectives/hypothesis</h4>No biomarkers are used to estimate the prognosis in oral cavity squamous cell carcinoma (OSCC). In our previously published work, we have reported the prognostic value of CD44 and hypoxia inducible factor (HIF)-1α in patients with stage I disease.<h4>Study design</h4>In this study, we tested our previous observations in a larger cohort. We also studied the predictive value of common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 in this material.<h4>Methods</h4>CD44, HIF1α, and CLEVER-1 were immunohistochemically analyzed in paraffin-embedded tissue material of stage I OSCC patients treated at three Finnish university hospitals. Microscopy results were correlated with OSCC outcome.<h4>Results</h4>As in our pilot study, the CD44<sup>low</sup2016-01-01T00:00:00Z2016 Feb2025-04-19T22:15:17.918Z2019-03-27T02:55:11ZS-EPMC55808572889479710.1002/lio2.3