{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(14)"],"submitter":["Oh KH"],"funding":["NIAAA NIH HHS"],"pubmed_abstract":["Aldicarb treatment causes an accumulation of acetylcholine in the synaptic cleft of the neuromuscular junction, resulting in sustained muscle activation and eventually paralysis. Aldicarb-induced paralysis assay is an easy and fast method to determine whether synaptic transmission of a <i>C. elegans</i> mutant of interest is altered. This assay is based on the correlation of the rate of neurotransmitter release with the rate of paralysis. In this protocol, we describe a method for simultaneously assessing the aldicarb sensitivity of animals with different genotypes."],"journal":["Bio-protocol"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5580937"],"repository":["biostudies-literature"],"pubmed_title":["Aldicarb-induced Paralysis Assay to Determine Defects in Synaptic Transmission in <i>Caenorhabditis elegans</i>."],"pmcid":["PMC5580937"],"funding_grant_id":["R21 AA023940"],"pubmed_authors":["Kim H","Oh KH"],"additional_accession":[]},"is_claimable":false,"name":"Aldicarb-induced Paralysis Assay to Determine Defects in Synaptic Transmission in <i>Caenorhabditis elegans</i>.","description":"Aldicarb treatment causes an accumulation of acetylcholine in the synaptic cleft of the neuromuscular junction, resulting in sustained muscle activation and eventually paralysis. Aldicarb-induced paralysis assay is an easy and fast method to determine whether synaptic transmission of a <i>C. elegans</i> mutant of interest is altered. This assay is based on the correlation of the rate of neurotransmitter release with the rate of paralysis. In this protocol, we describe a method for simultaneously assessing the aldicarb sensitivity of animals with different genotypes.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2022-02-11T11:05:09.936Z","creation":"2019-03-27T02:55:12Z"},"accession":"S-EPMC5580937","cross_references":{"pubmed":["28868330"],"doi":["10.21769/BioProtoc.2400","10.21769/bioprotoc.2400"]}}