{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(32)"],"submitter":["Fu SJ"],"pubmed_abstract":["NEK2 is a member of the NIMA-related family of serine/threonine centrosomal kinases. We analyzed the relationship between differential expression of NEK2 and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. We also studied the microRNAs that affect NEK2 expression. Analysis of multiple microarrays in the Oncomine database revealed that NEK2 expression was higher in HCC tissues than adjacent normal liver tissues. High NEK2 expression correlated with tumor size, pathological grade and macro- and microvascular invasion. Consequently, patients exhibiting high NEK2 expression had poorer prognosis. This was corroborated by our multivariate analysis that showed NEK2 to be an independent prognostic factor for HCC patient survival. Further, high NEK2 expression promoted prol"],"journal":["Oncotarget"],"pagination":["52948-52959"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5581084"],"repository":["biostudies-literature"],"pubmed_title":["MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma."],"pmcid":["PMC5581084"],"pubmed_authors":["Wu LW","Zhu XF","Chen J","Guo ZY","Ji F","Zhao Q","Ju WQ","Chen MG","Fu SJ","Wang DP","Ma Y","He XS"],"additional_accession":[]},"is_claimable":false,"name":"MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma.","description":"NEK2 is a member of the NIMA-related family of serine/threonine centrosomal kinases. We analyzed the relationship between differential expression of NEK2 and hepatocellular carcinoma (HCC) patient outcomes after liver transplants. We also studied the microRNAs that affect NEK2 expression. Analysis of multiple microarrays in the Oncomine database revealed that NEK2 expression was higher in HCC tissues than adjacent normal liver tissues. High NEK2 expression correlated with tumor size, pathological grade and macro- and microvascular invasion. Consequently, patients exhibiting high NEK2 expression had poorer prognosis. This was corroborated by our multivariate analysis that showed NEK2 to be an independent prognostic factor for HCC patient survival. Further, high NEK2 expression promoted prol","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-19T22:18:08.408Z","creation":"2019-03-27T02:55:13Z"},"accession":"S-EPMC5581084","cross_references":{"pubmed":["28881785"],"doi":["10.18632/oncotarget.17635"]}}