{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou JX"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS"],"pagination":["50594-50607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5584173"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(31)"],"pubmed_abstract":["Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six <i>KANSARL</i> (<i>KANSL1</i>-<i>ARL17A</i>) transcripts that resulted from the fusion between the <i>KANSL1</i> and <i>ARL17A</i> genes using a RNA splicingcode model. Five of these six <i>KANSARL</i> fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that <i>KANSARL</i> fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa. In contrast, they exist in 30 - "],"journal":["Oncotarget"],"pubmed_title":["Identification of <i>KANSARL</i> as the first cancer predisposition fusion gene specific to the population of European ancestry origin."],"pmcid":["PMC5584173"],"funding_grant_id":["R01 HL131013","R21 ES027058"],"pubmed_authors":["Zhou JX","Yang X","Ning S","Yuan F","Tang L","Zhuo DD","Zhang Y","Li F","Zhuo D","Wang K","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Identification of <i>KANSARL</i> as the first cancer predisposition fusion gene specific to the population of European ancestry origin.","description":"Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six <i>KANSARL</i> (<i>KANSL1</i>-<i>ARL17A</i>) transcripts that resulted from the fusion between the <i>KANSL1</i> and <i>ARL17A</i> genes using a RNA splicingcode model. Five of these six <i>KANSARL</i> fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that <i>KANSARL</i> fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa. In contrast, they exist in 30 - ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-05-01T08:56:44.539Z","creation":"2019-03-27T02:55:24Z"},"accession":"S-EPMC5584173","cross_references":{"pubmed":["28881586"],"doi":["10.18632/oncotarget.16385"]}}