biostudies-literatureZhou JXNIEHS NIH HHSNHLBI NIH HHS50594-50607https://www.ebi.ac.uk/biostudies/studies/S-EPMC5584173biostudies-literatureUnknown8(31)Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six <i>KANSARL</i> (<i>KANSL1</i>-<i>ARL17A</i>) transcripts that resulted from the fusion between the <i>KANSL1</i> and <i>ARL17A</i> genes using a RNA splicingcode model. Five of these six <i>KANSARL</i> fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that <i>KANSARL</i> fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa. In contrast, they exist in 30 - OncotargetIdentification of <i>KANSARL</i> as the first cancer predisposition fusion gene specific to the population of European ancestry origin.PMC5584173R01 HL131013R21 ES027058Zhou JXYang XNing SYuan FTang LZhuo DDZhang YLi FZhuo DWang KWang LfalseIdentification of <i>KANSARL</i> as the first cancer predisposition fusion gene specific to the population of European ancestry origin.Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six <i>KANSARL</i> (<i>KANSL1</i>-<i>ARL17A</i>) transcripts that resulted from the fusion between the <i>KANSL1</i> and <i>ARL17A</i> genes using a RNA splicingcode model. Five of these six <i>KANSARL</i> fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that <i>KANSARL</i> fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa. In contrast, they exist in 30 - 2017-01-01T00:00:00Z2017 Aug2026-05-01T08:56:44.539Z2019-03-27T02:55:24ZS-EPMC55841732888158610.18632/oncotarget.16385