biostudies-literatureUnknown8(31)Klaver CEL<h4>Objective</h4>Early detection of peritoneal metastases (PM) of colorectal cancer (CRC) is difficult and treatment options at a clinically overt stage are limited. Potentially, adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) is of value. The aim of this study was to present long term oncological outcomes of a pilot study on adjuvant HIPEC to reduce development of PMCRC, with systematic review of literature.<h4>Methods</h4>Long term oncological outcomes of ten patients who underwent laparoscopic HIPEC within eight weeks after resection of primary CRC in the pilot study were retrospectively collected. A systematic search of literature was performed on studies describing the use of HIPEC in patients with CRC at high risk of developing PM.<h4>Results</h4>The median fOncotarget51200-51209https://www.ebi.ac.uk/biostudies/studies/S-EPMC5584242biostudies-literatureColorectal cancer at high risk of peritoneal metastases: long term outcomes of a pilot study on adjuvant laparoscopic HIPEC and future perspectives.PMC5584242Bemelman WACrezee JPunt CJAStam RKlaver CELSloothaak DAMTanis PJfalseColorectal cancer at high risk of peritoneal metastases: long term outcomes of a pilot study on adjuvant laparoscopic HIPEC and future perspectives.<h4>Objective</h4>Early detection of peritoneal metastases (PM) of colorectal cancer (CRC) is difficult and treatment options at a clinically overt stage are limited. Potentially, adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) is of value. The aim of this study was to present long term oncological outcomes of a pilot study on adjuvant HIPEC to reduce development of PMCRC, with systematic review of literature.<h4>Methods</h4>Long term oncological outcomes of ten patients who underwent laparoscopic HIPEC within eight weeks after resection of primary CRC in the pilot study were retrospectively collected. A systematic search of literature was performed on studies describing the use of HIPEC in patients with CRC at high risk of developing PM.<h4>Results</h4>The median f2017-01-01T00:00:00Z2017 Aug2026-05-01T08:57:35.995Z2019-03-27T02:55:24ZS-EPMC55842422888164110.18632/oncotarget.17158