biostudies-literatureOrini MMarie Curie FellowshipUniversty College London Hospitals Biomedicine NIHRMedical Research Councile0183732https://www.ebi.ac.uk/biostudies/studies/S-EPMC5584807biostudies-literatureUnknown12(9)<h4>Background</h4>The heart rate (HR) response to exercise provides useful information about the autonomic function and has prognostic value, but its reproducibility over a long period of time, a critical requirement for using it as a clinical biomarker, is undetermined.<h4>Aim</h4>To determine the intra-individual reproducibility of HR dynamics during sub-maximum exercise and one minute recovery.<h4>Methods</h4>1187 individuals from the Cardio physical fitness assessment test of the UK Biobank repeated a standard exercise stress test twice (recall time 34.2 ± 2.8 months) and were prospectively studied.<h4>Results</h4>821 individuals complied with inclusion criteria for reproducibility analysis, including peak workload differences between assessments ≤10 W. Intra-individual correlation between HR profile during the first and the second assessment was very high and higher than inter-individual correlation (0.92±0.08 vs 0.87±0.11, p<0.01). Intra-individual correlation of indices describing HR dynamics was: ρ = 0.81 for maximum HR during exercise; ρ = 0.71 for minimum HR during recovery; ρ = 0.70 for HR changes during both exercise and recovery; Intra-individual correlation was higher for these indices of HR dynamics than for resting HR (ρ = 0.64). Bland-Altman plots demonstrated good agreement between HR indices estimated during the first and second assessment. A small but consistent bias was registered for all repeated measurements. The intra-individual consistency of abnormal values was about 60-70%.<h4>Conclusions</h4>The HR dynamics during exercise and recovery are reproducible over a period of 3 years, with moderate to strong intra-individual reproducibility of abnormal values.PloS oneLong-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.PMC5584807MC_QA137853MR/N025083/1Orini MLambiase PDTinker AMunroe PBfalseLong-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort.<h4>Background</h4>The heart rate (HR) response to exercise provides useful information about the autonomic function and has prognostic value, but its reproducibility over a long period of time, a critical requirement for using it as a clinical biomarker, is undetermined.<h4>Aim</h4>To determine the intra-individual reproducibility of HR dynamics during sub-maximum exercise and one minute recovery.<h4>Methods</h4>1187 individuals from the Cardio physical fitness assessment test of the UK Biobank repeated a standard exercise stress test twice (recall time 34.2 ± 2.8 months) and were prospectively studied.<h4>Results</h4>821 individuals complied with inclusion criteria for reproducibility analysis, including peak workload differences between assessments ≤10 W. Intra-individual correlation between HR profile during the first and the second assessment was very high and higher than inter-individual correlation (0.92±0.08 vs 0.87±0.11, p<0.01). Intra-individual correlation of indices describing HR dynamics was: ρ = 0.81 for maximum HR during exercise; ρ = 0.71 for minimum HR during recovery; ρ = 0.70 for HR changes during both exercise and recovery; Intra-individual correlation was higher for these indices of HR dynamics than for resting HR (ρ = 0.64). Bland-Altman plots demonstrated good agreement between HR indices estimated during the first and second assessment. A small but consistent bias was registered for all repeated measurements. The intra-individual consistency of abnormal values was about 60-70%.<h4>Conclusions</h4>The HR dynamics during exercise and recovery are reproducible over a period of 3 years, with moderate to strong intra-individual reproducibility of abnormal values.2017-01-01T00:00:00Z20172024-11-20T18:51:14.114Z2019-03-27T02:55:27ZS-EPMC55848072887339710.1371/journal.pone.0183732