{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tran A"],"funding":["NIDCD NIH HHS","NIH MARC Fellowship","NINDS NIH HHS","National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["e23770"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5584987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator-prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator <i>Caenorhabditis elegans</i> and the bacterial prey <i>Streptomyces,</i> which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to <i>Streptomyces</i> at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of <i>Streptomyces</i> secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation repre"],"journal":["eLife"],"pubmed_title":["<i>C. elegans</i> avoids toxin-producing <i>Streptomyces</i> using a seven transmembrane domain chemosensory receptor."],"pmcid":["PMC5584987"],"funding_grant_id":["T32 GM064337","HRD-1302873","NS087544","T34 GM008253","R01 DC005991","R01 NS087544","5SC3GM118199","5T34GM008253","SC3 GM118199","SC3 GM089595","GM089595","1355202"],"pubmed_authors":["Balistreri A","Jimenez V","Li J","Varshney A","Tang A","Duong A","Tran A","Levinson S","Eggers DK","L'Etoile N","Ali N","Woldemariam S","Bremer M","Coto Villa D","O'Loughlin CT","Matthews SY","Pyle J","Khuri S","Miller Conrad LC","Vargas C","Tsujimoto B","Chang E","Wellbrook C","VanHoven MK"],"additional_accession":[]},"is_claimable":false,"name":"<i>C. elegans</i> avoids toxin-producing <i>Streptomyces</i> using a seven transmembrane domain chemosensory receptor.","description":"Predators and prey co-evolve, each maximizing their own fitness, but the effects of predator-prey interactions on cellular and molecular machinery are poorly understood. Here, we study this process using the predator <i>Caenorhabditis elegans</i> and the bacterial prey <i>Streptomyces,</i> which have evolved a powerful defense: the production of nematicides. We demonstrate that upon exposure to <i>Streptomyces</i> at their head or tail, nematodes display an escape response that is mediated by bacterially produced cues. Avoidance requires a predicted G-protein-coupled receptor, SRB-6, which is expressed in five types of amphid and phasmid chemosensory neurons. We establish that species of <i>Streptomyces</i> secrete dodecanoic acid, which is sensed by SRB-6. This behavioral adaptation repre","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-04-13T21:48:57.485Z","creation":"2025-05-18T12:53:06.432Z"},"accession":"S-EPMC5584987","cross_references":{"pubmed":["28873053"],"doi":["10.7554/eLife.23770"]}}