biostudies-literatureHsu RCJThe Urology FoundationCancer Research UKAddenbrooke&apos;s Charitable TrustRoyal College of Surgeons of Englande016833https://www.ebi.ac.uk/biostudies/studies/S-EPMC5588977biostudies-literatureUnknown7(9)<h4>Objectives</h4>The provision of complex surgery is increasingly centralised to high-volume (HV) specialist hospitals. Evidence to support nephrectomy centralisation however has been inconsistent. We conducted a systematic review and meta-analysis to determine the association between hospital case volumes and perioperative outcomes in radical nephrectomy, partial nephrectomy and nephrectomy with venous thrombectomy.<h4>Methods</h4>Medline, Embase and the Cochrane Library were searched for relevant studies published between 1990 and 2016. Pooled effect estimates for nephrectomy mortality and complications were calculated for each nephrectomy type using the DerSimonian and Laird random-effects model. Sensitivity analyses were performed to examine the effects of heterogeneity on the pooledBMJ openInfluence of hospital volume on nephrectomy mortality and complications: a systematic review and meta-analysis stratified by surgical type.PMC558897718180Salika TMaw JArmitage JNHsu RCJLyratzopoulos GGnanapragasam VJfalseInfluence of hospital volume on nephrectomy mortality and complications: a systematic review and meta-analysis stratified by surgical type.<h4>Objectives</h4>The provision of complex surgery is increasingly centralised to high-volume (HV) specialist hospitals. Evidence to support nephrectomy centralisation however has been inconsistent. We conducted a systematic review and meta-analysis to determine the association between hospital case volumes and perioperative outcomes in radical nephrectomy, partial nephrectomy and nephrectomy with venous thrombectomy.<h4>Methods</h4>Medline, Embase and the Cochrane Library were searched for relevant studies published between 1990 and 2016. Pooled effect estimates for nephrectomy mortality and complications were calculated for each nephrectomy type using the DerSimonian and Laird random-effects model. Sensitivity analyses were performed to examine the effects of heterogeneity on the pooled2017-01-01T00:00:00Z2017 Sep2025-04-19T14:10:17.637Z2019-03-26T22:45:42ZS-EPMC55889772887794710.1136/bmjopen-2017-016833