{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng H"],"funding":["Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["1703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5594074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to treat IBD in clinic for years. However, how SASP affects gut microbes and its potential functions remains unclear. To investigate the relationships of SASP, IBD, and gut microbiome, we used 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce experimental colitis in rats, and analyzed the microbiota in the fecal samples, which come from the control group (treated with ethanol + saline), the model group (treated with TNBS-ethanol + saline) and the SASP group (treated with TNBS-ethanol + SASP), with 16S gene sequencing and followed up a subset sample using shotgun sequencing. The study found that SASP treatment could not only restore the TN"],"journal":["Frontiers in microbiology"],"pubmed_title":["Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine."],"pmcid":["PMC5594074"],"funding_grant_id":["No. 81473540","Grant No. 2015A030313123","No. 81473319"],"pubmed_authors":["Liao Z","Wang M","Li Y","Zheng H","Chen M","Xie Z","Liao Q","Wang Y","Wei L","Ma F"],"additional_accession":[]},"is_claimable":false,"name":"Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine.","description":"Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to treat IBD in clinic for years. However, how SASP affects gut microbes and its potential functions remains unclear. To investigate the relationships of SASP, IBD, and gut microbiome, we used 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce experimental colitis in rats, and analyzed the microbiota in the fecal samples, which come from the control group (treated with ethanol + saline), the model group (treated with TNBS-ethanol + saline) and the SASP group (treated with TNBS-ethanol + SASP), with 16S gene sequencing and followed up a subset sample using shotgun sequencing. The study found that SASP treatment could not only restore the TN","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-01T09:14:07.625Z","creation":"2019-03-27T02:56:04Z"},"accession":"S-EPMC5594074","cross_references":{"pubmed":["28936203"],"doi":["10.3389/fmicb.2017.01703"]}}