{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schneider A"],"funding":["NIA NIH HHS","Glenn Foundation for Medical Research","National Institutes of Health"],"pagination":["1200-1203"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5595684"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["Caloric restriction (CR) is one of the most robust interventions shown to delay aging in diverse species, including rhesus monkeys (Macaca mulatta). Identification of factors involved in CR brings a promise of translatability to human health and aging. Here, we show that CR induced a profound change in abundance of circulating microRNAs (miRNAs) linked to growth and insulin signaling pathway, suggesting that miRNAs are involved in CR's mechanisms of action in primates. Deep sequencing of plasma RNA extracts enriched for short species revealed a total of 243 unique species of miRNAs including 47 novel species. Approximately 70% of the plasma miRNAs detected were conserved between rhesus monkeys and humans. CR induced or repressed 24 known and 10 novel miRNA species. Regression analysis reve"],"journal":["Aging cell"],"pubmed_title":["Caloric restriction impacts plasma microRNAs in rhesus monkeys."],"pmcid":["PMC5595684"],"funding_grant_id":["AG000213","P50 AG033514","R56 AG047358","AG047358","T32 AG000213","R01 AG040178","AG040178"],"pubmed_authors":["Dhahbi JM","Atamna H","Schneider A","Clark JP","Colman RJ","Anderson RM"],"additional_accession":[]},"is_claimable":false,"name":"Caloric restriction impacts plasma microRNAs in rhesus monkeys.","description":"Caloric restriction (CR) is one of the most robust interventions shown to delay aging in diverse species, including rhesus monkeys (Macaca mulatta). Identification of factors involved in CR brings a promise of translatability to human health and aging. Here, we show that CR induced a profound change in abundance of circulating microRNAs (miRNAs) linked to growth and insulin signaling pathway, suggesting that miRNAs are involved in CR's mechanisms of action in primates. Deep sequencing of plasma RNA extracts enriched for short species revealed a total of 243 unique species of miRNAs including 47 novel species. Approximately 70% of the plasma miRNAs detected were conserved between rhesus monkeys and humans. CR induced or repressed 24 known and 10 novel miRNA species. Regression analysis reve","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-05-06T03:42:29.504Z","creation":"2019-03-27T02:56:07Z"},"accession":"S-EPMC5595684","cross_references":{"pubmed":["28677323"],"doi":["10.1111/acel.12636"]}}