{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ke Z"],"funding":["Consejo Nacional de Investigaciones Científicas y Técnicas","NIA NIH HHS","NCI NIH HHS","National Institutes of Health","Life Extension Foundation","NIGMS NIH HHS","NY Stem predoctoral fellowship"],"pagination":["988-993"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5595694"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["Whether errors in protein synthesis play a role in aging has been a subject of intense debate. It has been suggested that rare mistakes in protein synthesis in young organisms may result in errors in the protein synthesis machinery, eventually leading to an increasing cascade of errors as organisms age. Studies that followed generally failed to identify a dramatic increase in translation errors with aging. However, whether translation fidelity plays a role in aging remained an open question. To address this issue, we examined the relationship between translation fidelity and maximum lifespan across 17 rodent species with diverse lifespans. To measure translation fidelity, we utilized sensitive luciferase-based reporter constructs with mutations in an amino acid residue critical to lucifera"],"journal":["Aging cell"],"pubmed_title":["Translation fidelity coevolves with longevity."],"pmcid":["PMC5595694"],"funding_grant_id":["R01 CA080946","P01 AG047200","R01 AG046320","R01 AG027237","DP1 AG047745","R01 AG021518","R37 GM065204","R03 AG052365"],"pubmed_authors":["Johnson AB","Mallik P","Nevo E","Luna F","Gladyshev VN","Ke Z","Zhang ZD","Gorbunova V","Seluanov A"],"additional_accession":[]},"is_claimable":false,"name":"Translation fidelity coevolves with longevity.","description":"Whether errors in protein synthesis play a role in aging has been a subject of intense debate. It has been suggested that rare mistakes in protein synthesis in young organisms may result in errors in the protein synthesis machinery, eventually leading to an increasing cascade of errors as organisms age. Studies that followed generally failed to identify a dramatic increase in translation errors with aging. However, whether translation fidelity plays a role in aging remained an open question. To address this issue, we examined the relationship between translation fidelity and maximum lifespan across 17 rodent species with diverse lifespans. To measure translation fidelity, we utilized sensitive luciferase-based reporter constructs with mutations in an amino acid residue critical to lucifera","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-22T02:36:40.046Z","creation":"2019-03-27T02:56:07Z"},"accession":"S-EPMC5595694","cross_references":{"pubmed":["28707419"],"doi":["10.1111/acel.12628"]}}