{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Ramos CAF"],"funding":["CNPq","CAPES"],"pubmed_abstract":["The aim of the present work was to develop a biochemical, histologic and immunohistochemical study about the potential hepatotoxic effect of d-limonene - a component of volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) from d-limonene-treated animals were determined and compared to morphologic hepatic lesions in order to investigate the possible physiopathologic mechanisms involved in the liver toxicity, in experimental animals treated with d-limonene. Wistar rats were randomly divided into seven groups: two control groups (untreated or receiving only vehicle, tween-80); one positive control (vehicle); two experimental groups treated with d-limonene at doses of 25 mg/kg/day and 75 mg/kg/day for "],"journal":["Toxicology reports"],"pagination":["482-488"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5598502"],"repository":["biostudies-literature"],"pubmed_title":["Histopathological and biochemical assessment of d-limonene-induced liver injury in rats."],"pmcid":["PMC5598502"],"pubmed_authors":["Sa RCDS","de Almeida RN","Ramos CAF","Benedito RB","Alves MF","de Sousa DP","Diniz MFFM","Araujo MST"],"additional_accession":[]},"is_claimable":false,"name":"Histopathological and biochemical assessment of d-limonene-induced liver injury in rats.","description":"The aim of the present work was to develop a biochemical, histologic and immunohistochemical study about the potential hepatotoxic effect of d-limonene - a component of volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) from d-limonene-treated animals were determined and compared to morphologic hepatic lesions in order to investigate the possible physiopathologic mechanisms involved in the liver toxicity, in experimental animals treated with d-limonene. Wistar rats were randomly divided into seven groups: two control groups (untreated or receiving only vehicle, tween-80); one positive control (vehicle); two experimental groups treated with d-limonene at doses of 25 mg/kg/day and 75 mg/kg/day for ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-18T14:15:19.271Z","creation":"2019-03-27T02:56:21Z"},"accession":"S-EPMC5598502","cross_references":{"pubmed":["28962384"],"doi":["10.1016/j.toxrep.2015.01.001"]}}