biostudies-literatureUnknown2Ramos CAFCNPqCAPESThe aim of the present work was to develop a biochemical, histologic and immunohistochemical study about the potential hepatotoxic effect of d-limonene - a component of volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) from d-limonene-treated animals were determined and compared to morphologic hepatic lesions in order to investigate the possible physiopathologic mechanisms involved in the liver toxicity, in experimental animals treated with d-limonene. Wistar rats were randomly divided into seven groups: two control groups (untreated or receiving only vehicle, tween-80); one positive control (vehicle); two experimental groups treated with d-limonene at doses of 25 mg/kg/day and 75 mg/kg/day for Toxicology reports482-488https://www.ebi.ac.uk/biostudies/studies/S-EPMC5598502biostudies-literatureHistopathological and biochemical assessment of d-limonene-induced liver injury in rats.PMC5598502Sa RCDSde Almeida RNRamos CAFBenedito RBAlves MFde Sousa DPDiniz MFFMAraujo MSTfalseHistopathological and biochemical assessment of d-limonene-induced liver injury in rats.The aim of the present work was to develop a biochemical, histologic and immunohistochemical study about the potential hepatotoxic effect of d-limonene - a component of volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) from d-limonene-treated animals were determined and compared to morphologic hepatic lesions in order to investigate the possible physiopathologic mechanisms involved in the liver toxicity, in experimental animals treated with d-limonene. Wistar rats were randomly divided into seven groups: two control groups (untreated or receiving only vehicle, tween-80); one positive control (vehicle); two experimental groups treated with d-limonene at doses of 25 mg/kg/day and 75 mg/kg/day for 2015-01-01T00:00:00Z20152025-04-18T14:15:19.271Z2019-03-27T02:56:21ZS-EPMC55985022896238410.1016/j.toxrep.2015.01.001