biostudies-literatureUnknown91(19)Moore SJChronic wasting disease (CWD) is a naturally occurring, fatal neurodegenerative disease of cervids. The potential for swine to serve as hosts for the agent of CWD is unknown. The purpose of this study was to investigate the susceptibility of swine to the CWD agent following experimental oral or intracranial inoculation. Crossbred piglets were assigned to three groups, intracranially inoculated (n = 20), orally inoculated (n = 19), and noninoculated (n = 9). At approximately the age at which commercial pigs reach market weight, half of the pigs in each group were culled ("market weight" groups). The remaining pigs ("aged" groups) were allowed to incubate for up to 73 months postinoculation (mpi). Tissues collected at necropsy were examined for disease-associated prion protein (PrPSc) by WesJournal of virologye00926-17https://www.ebi.ac.uk/biostudies/studies/S-EPMC5599732biostudies-literatureExperimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation.PMC5599732Kanthasamy AManne SKunkle RAWest Greenlee MHGreenlee JJMoore SJKondru NSmith JDfalseExperimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation.Chronic wasting disease (CWD) is a naturally occurring, fatal neurodegenerative disease of cervids. The potential for swine to serve as hosts for the agent of CWD is unknown. The purpose of this study was to investigate the susceptibility of swine to the CWD agent following experimental oral or intracranial inoculation. Crossbred piglets were assigned to three groups, intracranially inoculated (n = 20), orally inoculated (n = 19), and noninoculated (n = 9). At approximately the age at which commercial pigs reach market weight, half of the pigs in each group were culled ("market weight" groups). The remaining pigs ("aged" groups) were allowed to incubate for up to 73 months postinoculation (mpi). Tissues collected at necropsy were examined for disease-associated prion protein (PrPSc) by Wes2017-01-01T00:00:00Z2017 Oct2025-04-04T09:54:03.949Z2019-03-27T02:56:27ZS-EPMC55997322870140710.1128/jvi.00926-1710.1128/JVI.00926-17