{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Martinez R"],"pubmed_abstract":["<h4>Background</h4>Growth hormone secretagogues (GHS), among other factors, regulate the release of GH. The biological activity of the secretagogue peptide A233 as a promoter of growth and innate immunity in teleost fish has previously been demonstrated, but its role in the immune system of mammals is not well understood.<h4>Methods</h4>The effect of the peptide was investigated in J774A.2 macrophage cells using a comparative proteomics approach after 6 and 12 h of peptide stimulation.<h4>Results</h4>The functional analysis of differentially modulated proteins showed that A233 peptide treatment appears to promote activation and ROS-dependent cytotoxic functions in macrophages and enhanced expression of antiviral protein complexes such as MAVS. In accordance with this hypothesis, we found t"],"journal":["Biochemistry and biophysics reports"],"pagination":["379-387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5600417"],"repository":["biostudies-literature"],"pubmed_title":["Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response."],"pmcid":["PMC5600417"],"pubmed_authors":["Gonzalez LJ","Ramos Y","Besada V","de Villavicencio-Diaz TN","Albericio F","Mendez M","Vonasek E","Marcos E","Hermida L","Martinez R","Rodriguez E","Gonzalez LG","Garay H","Sanchez A","Sanchez B","Masforrol Y","Estrada MP","Ferro JN"],"additional_accession":[]},"is_claimable":false,"name":"Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response.","description":"<h4>Background</h4>Growth hormone secretagogues (GHS), among other factors, regulate the release of GH. The biological activity of the secretagogue peptide A233 as a promoter of growth and innate immunity in teleost fish has previously been demonstrated, but its role in the immune system of mammals is not well understood.<h4>Methods</h4>The effect of the peptide was investigated in J774A.2 macrophage cells using a comparative proteomics approach after 6 and 12 h of peptide stimulation.<h4>Results</h4>The functional analysis of differentially modulated proteins showed that A233 peptide treatment appears to promote activation and ROS-dependent cytotoxic functions in macrophages and enhanced expression of antiviral protein complexes such as MAVS. In accordance with this hypothesis, we found t","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2026-04-15T17:10:59.428Z","creation":"2025-05-29T16:23:28.967Z"},"accession":"S-EPMC5600417","cross_references":{"pubmed":["28955845"],"doi":["10.1016/j.bbrep.2016.01.008"]}}