{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(36)"],"submitter":["Lin CM"],"pubmed_abstract":["7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from <i>Taxus</i> × <i>media</i> cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activities of DMGF on the metastatic processes of melanoma cells <i>in vivo</i> and <i>in vitro</i>. A transwell assay showed that DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). Moreover, DMGF did not influence tube formation but inhibited the migration of endothelial cells. Furthermore, animal models were used to monitor the effects of DMGF on tumor metastasis, and all models showed "],"journal":["Oncotarget"],"pagination":["60046-60059"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5601121"],"repository":["biostudies-literature"],"pubmed_title":["The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization."],"pmcid":["PMC5601121"],"pubmed_authors":["Chan YL","Tsai YH","Chung CH","Hwang CH","Chi KH","Lin YL","Tzou SC","Chen PR","Liao KW","Lin CM","Ke CY","Ho SY","Wang YS","Tsai NM","Chang J"],"additional_accession":[]},"is_claimable":false,"name":"The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization.","description":"7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from <i>Taxus</i> × <i>media</i> cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activities of DMGF on the metastatic processes of melanoma cells <i>in vivo</i> and <i>in vitro</i>. A transwell assay showed that DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). Moreover, DMGF did not influence tube formation but inhibited the migration of endothelial cells. Furthermore, animal models were used to monitor the effects of DMGF on tumor metastasis, and all models showed ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-05-29T16:29:24.072Z","creation":"2025-05-29T16:29:24.072Z"},"accession":"S-EPMC5601121","cross_references":{"pubmed":["28947953"],"doi":["10.18632/oncotarget.10960"]}}