{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(35)"],"submitter":["Kowalik A"],"pubmed_abstract":["Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p.G534E (c.1601G>A) variant of <i>HABP2</i> was recently reported as a risk factor for familial non-medullary thyroid cancer, including papillary thyroid carcinoma. We analyzed the incidence of the c.1601G>A variant of <i>HABP2</i> in a Polish population consisting of 326 cases of papillary thyroid carcinoma and 400 control individuals by DNA genotyping, performed by Sanger sequencing. The c.1601G>A variant was detected in 3.7% of sporadic papillary thyroid carcinoma cases and 4.7% of healthy controls, and we did not detect an association between this variant and sporadic papillary thyroid carcinoma risk (OR = 0.71, 95% CI: 0.33-1.51; <i>p</i> = 0.3758). Additionally, no significant associations were identified between clinical and pathological disease features, response to primary treatment, and clinical status at the end of the observation, and <i>HABP2</i> c.1601G>A genotype. In conclusion, the p.G534E variant of <i>HABP2</i> is not associated with sporadic papillary thyroid carcinoma risk in the Polish population."],"journal":["Oncotarget"],"pagination":["58304-58308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5601653"],"repository":["biostudies-literature"],"pubmed_title":["The p.G534E variant of <i>HABP2</i> is not associated with sporadic papillary thyroid carcinoma in a Polish population."],"pmcid":["PMC5601653"],"pubmed_authors":["Gozdz S","Kowalska A","Walczyk A","Kopczynski J","Gasior-Perczak D","Kowalik A","Chlopek M","Siolek M","Palyga I","Gromek M","Mezyk R"],"additional_accession":[]},"is_claimable":false,"name":"The p.G534E variant of <i>HABP2</i> is not associated with sporadic papillary thyroid carcinoma in a Polish population.","description":"Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p.G534E (c.1601G>A) variant of <i>HABP2</i> was recently reported as a risk factor for familial non-medullary thyroid cancer, including papillary thyroid carcinoma. We analyzed the incidence of the c.1601G>A variant of <i>HABP2</i> in a Polish population consisting of 326 cases of papillary thyroid carcinoma and 400 control individuals by DNA genotyping, performed by Sanger sequencing. The c.1601G>A variant was detected in 3.7% of sporadic papillary thyroid carcinoma cases and 4.7% of healthy controls, and we did not detect an association between this variant and sporadic papillary thyroid carcinoma risk (OR = 0.71, 95% CI: 0.33-1.51; <i>p</i> = 0.3758). Additionally, no significant associations were identified between clinical and pathological disease features, response to primary treatment, and clinical status at the end of the observation, and <i>HABP2</i> c.1601G>A genotype. In conclusion, the p.G534E variant of <i>HABP2</i> is not associated with sporadic papillary thyroid carcinoma risk in the Polish population.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2024-12-04T02:34:31.462Z","creation":"2019-03-27T02:56:34Z"},"accession":"S-EPMC5601653","cross_references":{"pubmed":["28938557"],"doi":["10.18632/oncotarget.16870"]}}