{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Fandos N"],"pubmed_abstract":["<h4>Introduction</h4>Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease.<h4>Methods</h4>Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifestyle Flagship Study. This population was followed-up for 72 months and their cortical Aβ burden was assessed with positron emission tomography.<h4>Results</h4>Cross-sectional and longitudinal analyses showed an inverse association of Aβ42/40 plasma ratios and cortical Aβ burden. Optimized as a screening tool, TP42/40 reached 81% positive predictive value of high cortical Aβ burden, which r"],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pagination":["179-187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5602863"],"repository":["biostudies-literature"],"pubmed_title":["Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals."],"pmcid":["PMC5602863"],"pubmed_authors":["AIBL Research Group","Perez-Grijalba V","Fowler C","Fandos N","Villemagne VL","Masters CL","Sarasa M","Olmos S","Pesini P","Bossa M","Doecke J"],"additional_accession":[]},"is_claimable":false,"name":"Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals.","description":"<h4>Introduction</h4>Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease.<h4>Methods</h4>Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifestyle Flagship Study. This population was followed-up for 72 months and their cortical Aβ burden was assessed with positron emission tomography.<h4>Results</h4>Cross-sectional and longitudinal analyses showed an inverse association of Aβ42/40 plasma ratios and cortical Aβ burden. Optimized as a screening tool, TP42/40 reached 81% positive predictive value of high cortical Aβ burden, which r","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-05T14:31:12.649Z","creation":"2019-03-27T02:56:39Z"},"accession":"S-EPMC5602863","cross_references":{"pubmed":["28948206"],"doi":["10.1016/j.dadm.2017.07.004"]}}