biostudies-literatureUnknown8Fandos N<h4>Introduction</h4>Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease.<h4>Methods</h4>Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifestyle Flagship Study. This population was followed-up for 72 months and their cortical Aβ burden was assessed with positron emission tomography.<h4>Results</h4>Cross-sectional and longitudinal analyses showed an inverse association of Aβ42/40 plasma ratios and cortical Aβ burden. Optimized as a screening tool, TP42/40 reached 81% positive predictive value of high cortical Aβ burden, which rAlzheimer's & dementia (Amsterdam, Netherlands)179-187https://www.ebi.ac.uk/biostudies/studies/S-EPMC5602863biostudies-literaturePlasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals.PMC5602863AIBL Research GroupPerez-Grijalba VFowler CFandos NVillemagne VLMasters CLSarasa MOlmos SPesini PBossa MDoecke JfalsePlasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals.<h4>Introduction</h4>Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease.<h4>Methods</h4>Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifestyle Flagship Study. This population was followed-up for 72 months and their cortical Aβ burden was assessed with positron emission tomography.<h4>Results</h4>Cross-sectional and longitudinal analyses showed an inverse association of Aβ42/40 plasma ratios and cortical Aβ burden. Optimized as a screening tool, TP42/40 reached 81% positive predictive value of high cortical Aβ burden, which r2017-01-01T00:00:00Z20172025-04-05T14:31:12.649Z2019-03-27T02:56:39ZS-EPMC56028632894820610.1016/j.dadm.2017.07.004