{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun Y"],"funding":["National Institute of Allergy and Infectious Diseases","NEI NIH HHS","National Eye Institute","NIAID NIH HHS","Boston Children's Hospital","BrightFocus Foundation","National Institutes of Health"],"pagination":["4492-4502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5602899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(10)"],"pubmed_abstract":["Pathological proliferation of retinal blood vessels commonly causes vision impairment in proliferative retinopathies, including retinopathy of prematurity. Dysregulated crosstalk between the vasculature and retinal neurons is increasingly recognized as a major factor contributing to the pathogenesis of vascular diseases. Class 3 semaphorins (SEMA3s), a group of neuron-secreted axonal and vascular guidance factors, suppress pathological vascular growth in retinopathy. However, the upstream transcriptional regulators that mediate the function of SEMA3s in vascular growth are poorly understood. Here we showed that retinoic acid receptor-related orphan receptor α (RORα), a nuclear receptor and transcription factor, is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling "],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis."],"pmcid":["PMC5602899"],"funding_grant_id":["1R01 AI116885-01A1","R01 AI116885","R01 EY024963"],"pubmed_authors":["Liu CH","SanGiovanni JP","Chen J","Solt LA","Meng SS","Kamenecka TM","Sun Y","Wang Z","Burnim SB"],"additional_accession":[]},"is_claimable":false,"name":"RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.","description":"Pathological proliferation of retinal blood vessels commonly causes vision impairment in proliferative retinopathies, including retinopathy of prematurity. Dysregulated crosstalk between the vasculature and retinal neurons is increasingly recognized as a major factor contributing to the pathogenesis of vascular diseases. Class 3 semaphorins (SEMA3s), a group of neuron-secreted axonal and vascular guidance factors, suppress pathological vascular growth in retinopathy. However, the upstream transcriptional regulators that mediate the function of SEMA3s in vascular growth are poorly understood. Here we showed that retinoic acid receptor-related orphan receptor α (RORα), a nuclear receptor and transcription factor, is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-05T14:31:18.495Z","creation":"2019-03-26T23:57:51Z"},"accession":"S-EPMC5602899","cross_references":{"pubmed":["28646017"],"doi":["10.1096/fj.201700172R","10.1096/fj.201700172r"]}}