{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gong H"],"funding":["National Natural Science Foundation of China"],"pagination":["6506953"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5603328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2017"],"pubmed_abstract":["<h4>Background</h4>IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute conditions in a mouse model.<h4>Methods</h4>A number of cellular and molecular techniques were used to detect the differences between IRAK-M knockout (KO) and wild type (WT) mice exposed to 3-day or 7-week CS.<h4>Results</h4>Airway inflammation was comparable between IRAK-M KO and WT mice under 3-day CS exposure. Upon short-term CS exposure and lipopolysaccharide (LPS) inhalation, IRAK-M KO mice demonstrated worse airway inflammation, significantly higher percentage of Th17 cells and concentrations of proinflammatory cytokines in the lungs, "],"journal":["Mediators of inflammation"],"pubmed_title":["Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking."],"pmcid":["PMC5603328"],"funding_grant_id":["81170040","81470229"],"pubmed_authors":["Chen W","Gao J","Zhou W","Liu T","Gong H"],"additional_accession":[]},"is_claimable":false,"name":"Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking.","description":"<h4>Background</h4>IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute conditions in a mouse model.<h4>Methods</h4>A number of cellular and molecular techniques were used to detect the differences between IRAK-M knockout (KO) and wild type (WT) mice exposed to 3-day or 7-week CS.<h4>Results</h4>Airway inflammation was comparable between IRAK-M KO and WT mice under 3-day CS exposure. Upon short-term CS exposure and lipopolysaccharide (LPS) inhalation, IRAK-M KO mice demonstrated worse airway inflammation, significantly higher percentage of Th17 cells and concentrations of proinflammatory cytokines in the lungs, ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-04T09:43:49.511Z","creation":"2020-11-19T11:16:54Z"},"accession":"S-EPMC5603328","cross_references":{"pubmed":["28951634"],"doi":["10.1155/2017/6506953"]}}