biostudies-literatureGong HNational Natural Science Foundation of China6506953https://www.ebi.ac.uk/biostudies/studies/S-EPMC5603328biostudies-literatureUnknown2017<h4>Background</h4>IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute conditions in a mouse model.<h4>Methods</h4>A number of cellular and molecular techniques were used to detect the differences between IRAK-M knockout (KO) and wild type (WT) mice exposed to 3-day or 7-week CS.<h4>Results</h4>Airway inflammation was comparable between IRAK-M KO and WT mice under 3-day CS exposure. Upon short-term CS exposure and lipopolysaccharide (LPS) inhalation, IRAK-M KO mice demonstrated worse airway inflammation, significantly higher percentage of Th17 cells and concentrations of proinflammatory cytokines in the lungs, Mediators of inflammationEffect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking.PMC56033288117004081470229Chen WGao JZhou WLiu TGong HfalseEffect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking.<h4>Background</h4>IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute conditions in a mouse model.<h4>Methods</h4>A number of cellular and molecular techniques were used to detect the differences between IRAK-M knockout (KO) and wild type (WT) mice exposed to 3-day or 7-week CS.<h4>Results</h4>Airway inflammation was comparable between IRAK-M KO and WT mice under 3-day CS exposure. Upon short-term CS exposure and lipopolysaccharide (LPS) inhalation, IRAK-M KO mice demonstrated worse airway inflammation, significantly higher percentage of Th17 cells and concentrations of proinflammatory cytokines in the lungs, 2017-01-01T00:00:00Z20172025-04-04T09:43:49.511Z2020-11-19T11:16:54ZS-EPMC56033282895163410.1155/2017/6506953