{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang XS"],"funding":["National Natural Science Foundation of China","USDA | National Institute of Food and Agriculture"],"pagination":["E7832-E7840"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5604040"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(37)"],"pubmed_abstract":["Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth <i>Helicoverpa armigera</i>, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO through PRMT1-mediated methylation. These results suggest a distinct signaling pathway culminating in the elevation of FoxO, which in turn promotes the extension of life span characteristic of diapause."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Reactive oxygen species extend insect life span using components of the insulin-signaling pathway."],"pmcid":["PMC5604040"],"funding_grant_id":["2015-67013-23416","31230066"],"pubmed_authors":["Lin XW","Wang T","Xu WH","Zhang XS","Denlinger DL"],"additional_accession":[]},"is_claimable":false,"name":"Reactive oxygen species extend insect life span using components of the insulin-signaling pathway.","description":"Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth <i>Helicoverpa armigera</i>, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as evidenced by the facts that Akt, p-Akt, and PRMT1 are elevated by ROS, but not insulin, and that high levels of p-Akt fail to phosphorylate FoxO through PRMT1-mediated methylation. These results suggest a distinct signaling pathway culminating in the elevation of FoxO, which in turn promotes the extension of life span characteristic of diapause.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2024-11-05T20:56:29.341Z","creation":"2019-03-26T23:08:41Z"},"accession":"S-EPMC5604040","cross_references":{"pubmed":["28847950"],"doi":["10.1073/pnas.1711042114"]}}