biostudies-literatureUnknown12(9)Jardel S<h4>Objective</h4>To assess in clinical practice the frequency and diagnosis associated with the SS-B-positive/SS-A negative autoantibody profile.<h4>Methods</h4>We analyzed a one-year consecutive population of 624 patients referred by clinicians to the immunology laboratory to investigate anti-SS-A and/or anti-SS-B autoantibodies, who were detected using luminex technology. Data were analyzed for patients with isolated anti-SS-B autoantibodies. The clinical characteristics and diagnosis of connective tissue diseases (CTD) were retrieved according to the international criteria.<h4>Results</h4>Among 1173 sera positive for anti-SS-A and/or anti-SS-B autoantibodies from 624 patients, we identified 84 patients (13.5%) that had isolated anti-SS-B. Among the 75 patients positive for anti-SS-B wiPloS onee0185104https://www.ebi.ac.uk/biostudies/studies/S-EPMC5607193biostudies-literatureIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases: Results from a routine population survey.PMC5607193Coutant FHot ADurieu ILega JCJardel STebib JCottin VReynaud QGarnier LBelot AFabien NVukusic SSeve PLaville MfalseIsolated positive anti-SS-B autoantibodies are not related to clinical features of systemic autoimmune diseases: Results from a routine population survey.<h4>Objective</h4>To assess in clinical practice the frequency and diagnosis associated with the SS-B-positive/SS-A negative autoantibody profile.<h4>Methods</h4>We analyzed a one-year consecutive population of 624 patients referred by clinicians to the immunology laboratory to investigate anti-SS-A and/or anti-SS-B autoantibodies, who were detected using luminex technology. Data were analyzed for patients with isolated anti-SS-B autoantibodies. The clinical characteristics and diagnosis of connective tissue diseases (CTD) were retrieved according to the international criteria.<h4>Results</h4>Among 1173 sera positive for anti-SS-A and/or anti-SS-B autoantibodies from 624 patients, we identified 84 patients (13.5%) that had isolated anti-SS-B. Among the 75 patients positive for anti-SS-B wi2017-01-01T00:00:00Z20172025-04-18T19:36:44.917Z2019-03-27T02:56:57ZS-EPMC56071932893106010.1371/journal.pone.0185104