{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(38)"],"submitter":["Tsai FJ"],"pubmed_abstract":["Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (<i>P</i> < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu-Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and"],"journal":["Oncotarget"],"pagination":["63528-63550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5609941"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress."],"pmcid":["PMC5609941"],"pubmed_authors":["Lin JC","Li TM","Liao CC","Lin CC","Ho TJ","Cheng CF","Lin TH","Lin YJ","Liu X","Tsang H","Tsai FJ","Ko CH","Liang WM","Li JP","Huang SM"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress.","description":"Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (<i>P</i> < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu-Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-04-26T11:11:51.54Z","creation":"2019-03-27T02:57:09Z"},"accession":"S-EPMC5609941","cross_references":{"pubmed":["28969009"],"doi":["10.18632/oncotarget.18846"]}}