{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Credendino SC"],"funding":["Ministero dell’Istruzione, dell’Università e della Ricerca"],"pagination":["9769171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5610845"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2017"],"pubmed_abstract":["lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-A"],"journal":["International journal of genomics"],"pubmed_title":["Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse."],"pmcid":["PMC5610845"],"funding_grant_id":["FP7-PEOPLE-2012-IRSES","PON03PE_00060_7","RNA_REGULOMICS 318981"],"pubmed_authors":["Lewin N","Nardone A","Basu S","Di Guida L","Sanges R","Amendola E","De Felice M","Credendino SC","De Vita G","de Oliveira M","D'Andrea B"],"additional_accession":[]},"is_claimable":false,"name":"Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse.","description":"lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-A","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-26T11:13:35.712Z","creation":"2019-03-27T02:57:13Z"},"accession":"S-EPMC5610845","cross_references":{"pubmed":["29082235"],"doi":["10.1155/2017/9769171"]}}