biostudies-literatureCredendino SCMinistero dell’Istruzione, dell’Università e della Ricerca9769171https://www.ebi.ac.uk/biostudies/studies/S-EPMC5610845biostudies-literatureUnknown2017lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-AInternational journal of genomicsTissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse.PMC5610845FP7-PEOPLE-2012-IRSESPON03PE_00060_7RNA_REGULOMICS 318981Lewin NNardone ABasu SDi Guida LSanges RAmendola EDe Felice MCredendino SCDe Vita Gde Oliveira MD'Andrea BfalseTissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse.lncRNAs are acquiring increasing relevance as regulators in a wide spectrum of biological processes. The extreme heterogeneity in the mechanisms of action of these molecules, however, makes them very difficult to study, especially regarding their molecular function. A novel lncRNA has been recently identified as the most enriched transcript in mouse developing thyroid. Due to its genomic localization antisense to the protein-encoding Klhl14 gene, we named it Klhl14-AS. In this paper, we highlight that mouse Klhl14-AS produces at least five splicing variants, some of which have not been previously described. Klhl14-AS is expressed with a peculiar pattern, characterized by diverse relative abundance of its isoforms in different mouse tissues. We examine the whole expression level of Klhl14-A2017-01-01T00:00:00Z20172025-04-26T11:13:35.712Z2019-03-27T02:57:13ZS-EPMC56108452908223510.1155/2017/9769171