{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Gerke O"],"pubmed_abstract":["<h4>Background</h4>Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential analysis strategy in an intra-observer study on quantitative FDG-PET/CT measurements, illuminating the possibility of early trial termination which implicates significant potential time and resource savings.<h4>Methods</h4>Primary lesion maximum standardised uptake value (SUVmax) was determined twice from preoperative FDG-PET/CTs in 45 ovarian cancer patients. Differences in SUVmax were assumed to be normally distributed, and sequential one-sided hypothesis tests on the population standard deviation of the differences against a hypothesised value of 1.5 were perfor"],"journal":["EJNMMI research"],"pagination":["79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5615083"],"repository":["biostudies-literature"],"pubmed_title":["Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study."],"pmcid":["PMC5615083"],"pubmed_authors":["Vilstrup MH","Gerke O","Hildebrandt MG","Halekoh U","Hoilund-Carlsen PF"],"additional_accession":[]},"is_claimable":false,"name":"Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study.","description":"<h4>Background</h4>Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential analysis strategy in an intra-observer study on quantitative FDG-PET/CT measurements, illuminating the possibility of early trial termination which implicates significant potential time and resource savings.<h4>Methods</h4>Primary lesion maximum standardised uptake value (SUVmax) was determined twice from preoperative FDG-PET/CTs in 45 ovarian cancer patients. Differences in SUVmax were assumed to be normally distributed, and sequential one-sided hypothesis tests on the population standard deviation of the differences against a hypothesised value of 1.5 were perfor","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-04-22T11:47:41.229Z","creation":"2019-03-27T02:57:26Z"},"accession":"S-EPMC5615083","cross_references":{"pubmed":["28952076"],"doi":["10.1186/s13550-017-0328-6"]}}