{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Talan DA"],"funding":["NIDDK NIH HHS"],"pagination":["1-11.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5616169"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(1)"],"pubmed_abstract":["<h4>Study objective</h4>Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated outpatient treatment and no US randomized trial has been conducted, to our knowledge. This pilot study assessed feasibility of a multicenter US study comparing antibiotics-first, including outpatient management, with appendectomy.<h4>Methods</h4>Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole. Stable antibiotics-first-treated participants older than 13 years could be discharged after greater than or equal to 6-hour emergency department (ED) observation with next-day follow-"],"journal":["Annals of emergency medicine"],"pubmed_title":["Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management."],"pmcid":["PMC5616169"],"funding_grant_id":["R21 DK102048"],"pubmed_authors":["Lee S","Talan DA","Amii R","Taira B","Rouhani A","Sayegh C","Pathmarajah K","Jeng AC","Waxman M","Quinteros N","Lundberg S","Wu JX","Martin G","Morim A","Salem R","Ehlers A","McCollough M","Gibbons M","Seloadji P","Mason R","Begaz T","Schmit P","Lovato L","Moran GJ","Hiyama D","Krishnadasan A","DeUgarte DA","Chen F","Hui J","Uribe LA","Garrett A","Bennion R","Olive View–UCLA Appendicitis Study Group","De La Guerra JA","Saltzman DJ","Gonzalez E","Davidson G","Dunn J","Brunicardi FC","Diaz J","Torrez R","Cheaito A","Flum D","Dyne P","Mower WR","Abrahamian FM","Jude CM","Chiem A"],"additional_accession":[]},"is_claimable":false,"name":"Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management.","description":"<h4>Study objective</h4>Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated outpatient treatment and no US randomized trial has been conducted, to our knowledge. This pilot study assessed feasibility of a multicenter US study comparing antibiotics-first, including outpatient management, with appendectomy.<h4>Methods</h4>Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole. Stable antibiotics-first-treated participants older than 13 years could be discharged after greater than or equal to 6-hour emergency department (ED) observation with next-day follow-","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jul","modification":"2026-04-16T11:06:36.483Z","creation":"2019-03-26T23:44:06Z"},"accession":"S-EPMC5616169","cross_references":{"pubmed":["27974169"],"doi":["10.1016/j.annemergmed.2016.08.446"]}}