biostudies-literatureTalan DANIDDK NIH HHS1-11.e9https://www.ebi.ac.uk/biostudies/studies/S-EPMC5616169biostudies-literatureUnknown70(1)<h4>Study objective</h4>Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated outpatient treatment and no US randomized trial has been conducted, to our knowledge. This pilot study assessed feasibility of a multicenter US study comparing antibiotics-first, including outpatient management, with appendectomy.<h4>Methods</h4>Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole. Stable antibiotics-first-treated participants older than 13 years could be discharged after greater than or equal to 6-hour emergency department (ED) observation with next-day follow-Annals of emergency medicineAntibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management.PMC5616169R21 DK102048Lee STalan DAAmii RTaira BRouhani ASayegh CPathmarajah KJeng ACWaxman MQuinteros NLundberg SWu JXMartin GMorim ASalem REhlers AMcCollough MGibbons MSeloadji PMason RBegaz TSchmit PLovato LMoran GJHiyama DKrishnadasan ADeUgarte DAChen FHui JUribe LAGarrett ABennion ROlive View–UCLA Appendicitis Study GroupDe La Guerra JASaltzman DJGonzalez EDavidson GDunn JBrunicardi FCDiaz JTorrez RCheaito AFlum DDyne PMower WRAbrahamian FMJude CMChiem AfalseAntibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management.<h4>Study objective</h4>Randomized trials suggest that nonoperative treatment of uncomplicated appendicitis with antibiotics-first is safe. No trial has evaluated outpatient treatment and no US randomized trial has been conducted, to our knowledge. This pilot study assessed feasibility of a multicenter US study comparing antibiotics-first, including outpatient management, with appendectomy.<h4>Methods</h4>Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole. Stable antibiotics-first-treated participants older than 13 years could be discharged after greater than or equal to 6-hour emergency department (ED) observation with next-day follow-2017-01-01T00:00:00Z2017 Jul2026-04-16T11:06:36.483Z2019-03-26T23:44:06ZS-EPMC56161692797416910.1016/j.annemergmed.2016.08.446