{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(9)"],"submitter":["Shibutani M"],"pubmed_abstract":["Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms that include poor social communication, restricted interests, and repetitive behaviors. Several ASD mouse models exhibit impaired social interaction, anxiety-like behavior, and elevated perseveration. Large-scale whole exome sequencing studies identified many genes putatively associated with ASD. Like chromodomain helicase DNA binding protein 8 (CHD8), the most frequently mutated gene in individuals with ASD, the candidate gene <i>AT-rich interaction domain 1B</i> (<i>ARID1B</i>) encodes a chromatin remodeling factor. <i>Arid1b</i> heterozygous knockout (hKO) mice exhibited ASD-like traits related to social behavior, anxiety, and perseveration, in addition to associated features reported in some cases of ASD"],"journal":["International journal of molecular sciences"],"pagination":["E1872"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5618521"],"repository":["biostudies-literature"],"pubmed_title":["Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice."],"pmcid":["PMC5618521"],"pubmed_authors":["Miyakawa T","Terawaki N","Hatada I","Shibutani M","Shoji H","Horii T","Morita S","Kimura M"],"additional_accession":[]},"is_claimable":false,"name":"Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice.","description":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms that include poor social communication, restricted interests, and repetitive behaviors. Several ASD mouse models exhibit impaired social interaction, anxiety-like behavior, and elevated perseveration. Large-scale whole exome sequencing studies identified many genes putatively associated with ASD. Like chromodomain helicase DNA binding protein 8 (CHD8), the most frequently mutated gene in individuals with ASD, the candidate gene <i>AT-rich interaction domain 1B</i> (<i>ARID1B</i>) encodes a chromatin remodeling factor. <i>Arid1b</i> heterozygous knockout (hKO) mice exhibited ASD-like traits related to social behavior, anxiety, and perseveration, in addition to associated features reported in some cases of ASD","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-07-15T15:18:15.876Z","creation":"2019-03-27T02:57:37Z"},"accession":"S-EPMC5618521","cross_references":{"pubmed":["28867767"],"doi":["10.3390/ijms18091872"]}}