{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(10)"],"submitter":["Jallades L"],"pubmed_abstract":["Splenic diffuse red pulp lymphoma is an indolent small B-cell lymphoma recognized as a provisional entity in the World Health Organization 2008 classification. Its precise relationship to other related splenic B-cell lymphomas with frequent leukemic involvement or other lymphoproliferative disorders remains undetermined. We performed whole-exome sequencing to explore the genetic landscape of ten cases of splenic diffuse red pulp lymphoma using paired tumor and normal samples. A selection of 109 somatic mutations was then evaluated in a cohort including 42 samples of splenic diffuse red pulp lymphoma and compared to those identified in 46 samples of splenic marginal zone lymphoma and eight samples of hairy-cell leukemia. Recurrent mutations or losses in <i>BCOR</i> (the gene encoding the BC"],"journal":["Haematologica"],"pagination":["1758-1766"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5622860"],"repository":["biostudies-literature"],"pubmed_title":["Exome sequencing identifies recurrent <i>BCOR</i> alterations and the absence of <i>KLF2</i>, <i>TNFAIP3</i> and <i>MYD88</i> mutations in splenic diffuse red pulp small B-cell lymphoma."],"pmcid":["PMC5622860"],"pubmed_authors":["Verney A","Desvignes JP","Hayette S","Magaud JP","Salles G","Jallades L","Salgado D","Beroud C","Berger F","Huet S","Callet-Bauchu E","Genestier L","Chabane K","Baseggio L","Sujobert P","Traverse-Glehen A","Levy N","Felman P"],"additional_accession":[]},"is_claimable":false,"name":"Exome sequencing identifies recurrent <i>BCOR</i> alterations and the absence of <i>KLF2</i>, <i>TNFAIP3</i> and <i>MYD88</i> mutations in splenic diffuse red pulp small B-cell lymphoma.","description":"Splenic diffuse red pulp lymphoma is an indolent small B-cell lymphoma recognized as a provisional entity in the World Health Organization 2008 classification. Its precise relationship to other related splenic B-cell lymphomas with frequent leukemic involvement or other lymphoproliferative disorders remains undetermined. We performed whole-exome sequencing to explore the genetic landscape of ten cases of splenic diffuse red pulp lymphoma using paired tumor and normal samples. A selection of 109 somatic mutations was then evaluated in a cohort including 42 samples of splenic diffuse red pulp lymphoma and compared to those identified in 46 samples of splenic marginal zone lymphoma and eight samples of hairy-cell leukemia. Recurrent mutations or losses in <i>BCOR</i> (the gene encoding the BC","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-05-06T04:10:05.39Z","creation":"2019-07-24T07:12:28Z"},"accession":"S-EPMC5622860","cross_references":{"pubmed":["28751561"],"doi":["10.3324/haematol.2016.160192"]}}