biostudies-literatureUnknown102(10)Jallades LSplenic diffuse red pulp lymphoma is an indolent small B-cell lymphoma recognized as a provisional entity in the World Health Organization 2008 classification. Its precise relationship to other related splenic B-cell lymphomas with frequent leukemic involvement or other lymphoproliferative disorders remains undetermined. We performed whole-exome sequencing to explore the genetic landscape of ten cases of splenic diffuse red pulp lymphoma using paired tumor and normal samples. A selection of 109 somatic mutations was then evaluated in a cohort including 42 samples of splenic diffuse red pulp lymphoma and compared to those identified in 46 samples of splenic marginal zone lymphoma and eight samples of hairy-cell leukemia. Recurrent mutations or losses in <i>BCOR</i> (the gene encoding the BCHaematologica1758-1766https://www.ebi.ac.uk/biostudies/studies/S-EPMC5622860biostudies-literatureExome sequencing identifies recurrent <i>BCOR</i> alterations and the absence of <i>KLF2</i>, <i>TNFAIP3</i> and <i>MYD88</i> mutations in splenic diffuse red pulp small B-cell lymphoma.PMC5622860Verney ADesvignes JPHayette SMagaud JPSalles GJallades LSalgado DBeroud CBerger FHuet SCallet-Bauchu EGenestier LChabane KBaseggio LSujobert PTraverse-Glehen ALevy NFelman PfalseExome sequencing identifies recurrent <i>BCOR</i> alterations and the absence of <i>KLF2</i>, <i>TNFAIP3</i> and <i>MYD88</i> mutations in splenic diffuse red pulp small B-cell lymphoma.Splenic diffuse red pulp lymphoma is an indolent small B-cell lymphoma recognized as a provisional entity in the World Health Organization 2008 classification. Its precise relationship to other related splenic B-cell lymphomas with frequent leukemic involvement or other lymphoproliferative disorders remains undetermined. We performed whole-exome sequencing to explore the genetic landscape of ten cases of splenic diffuse red pulp lymphoma using paired tumor and normal samples. A selection of 109 somatic mutations was then evaluated in a cohort including 42 samples of splenic diffuse red pulp lymphoma and compared to those identified in 46 samples of splenic marginal zone lymphoma and eight samples of hairy-cell leukemia. Recurrent mutations or losses in <i>BCOR</i> (the gene encoding the BC2017-01-01T00:00:00Z2017 Oct2026-05-06T04:10:05.39Z2019-07-24T07:12:28ZS-EPMC56228602875156110.3324/haematol.2016.160192