{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Japan Agency for Medical Research and Development","Ministry of Education, Culture, Sports, Science and Technology"],"pagination":["1598-1610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5623699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["Assisted reproductive technologies, including <i>in vitro</i> fertilization (IVF), are now frequently used, and increasing evidence indicates that IVF causes gene expression changes in children and adolescents that increase the risk of metabolic diseases. Although such gene expression changes are thought to be due to IVF-induced epigenetic changes, the mechanism remains elusive. We tested whether the transcription factor ATF7-which mediates stress-induced changes in histone H3K9 tri- and dimethylation, typical marks of epigenetic silencing-is involved in the IVF-induced gene expression changes. IVF up- and downregulated the expression of 688 and 204 genes, respectively, in the liver of 3-week-old wild-type (WT) mice, whereas 87% and 68% of these were not changed, respectively, by IVF in AT"],"journal":["FEBS open bio"],"pubmed_title":["The transcription factor ATF7 mediates <i>in vitro</i> fertilization-induced gene expression changes in mouse liver."],"pmcid":["PMC5623699"],"funding_grant_id":["16H01413"],"pubmed_authors":["Liu Y","Maekawa T","Kaneda H","Chatton B","Wakana S","Yoshida K","Ishii S"],"additional_accession":[]},"is_claimable":false,"name":"The transcription factor ATF7 mediates <i>in vitro</i> fertilization-induced gene expression changes in mouse liver.","description":"Assisted reproductive technologies, including <i>in vitro</i> fertilization (IVF), are now frequently used, and increasing evidence indicates that IVF causes gene expression changes in children and adolescents that increase the risk of metabolic diseases. Although such gene expression changes are thought to be due to IVF-induced epigenetic changes, the mechanism remains elusive. We tested whether the transcription factor ATF7-which mediates stress-induced changes in histone H3K9 tri- and dimethylation, typical marks of epigenetic silencing-is involved in the IVF-induced gene expression changes. IVF up- and downregulated the expression of 688 and 204 genes, respectively, in the liver of 3-week-old wild-type (WT) mice, whereas 87% and 68% of these were not changed, respectively, by IVF in AT","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-05-02T11:09:52.246Z","creation":"2019-03-27T02:57:57Z"},"accession":"S-EPMC5623699","cross_references":{"pubmed":["28979846"],"doi":["10.1002/2211-5463.12304"]}}