biostudies-literatureSaldanha IJNEI NIH HHS933-940https://www.ebi.ac.uk/biostudies/studies/S-EPMC5625342biostudies-literatureUnknown135(9)<h4>Importance</h4>Suboptimal overlap in outcomes reported in clinical trials and systematic reviews compromises efforts to compare and summarize results across these studies.<h4>Objectives</h4>To examine the most frequent outcomes used in trials and reviews of the 4 most prevalent eye diseases (age-related macular degeneration [AMD], cataract, diabetic retinopathy [DR], and glaucoma) and the overlap between outcomes in the reviews and the trials included in the reviews.<h4>Design, setting, and participants</h4>This cross-sectional study examined all Cochrane reviews that addressed AMD, cataract, DR, and glaucoma; were published as of July 20, 2016; and included at least 1 trial and the trials included in the reviews. For each disease, a pair of clinical experts independently classified alJAMA ophthalmologyComparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases.PMC5625342U01 EY020522Saldanha IJJones LSColeman ALLindsley KDo DVVirgili GMeyerle CChuck RSJampel HDDickersin KfalseComparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases.<h4>Importance</h4>Suboptimal overlap in outcomes reported in clinical trials and systematic reviews compromises efforts to compare and summarize results across these studies.<h4>Objectives</h4>To examine the most frequent outcomes used in trials and reviews of the 4 most prevalent eye diseases (age-related macular degeneration [AMD], cataract, diabetic retinopathy [DR], and glaucoma) and the overlap between outcomes in the reviews and the trials included in the reviews.<h4>Design, setting, and participants</h4>This cross-sectional study examined all Cochrane reviews that addressed AMD, cataract, DR, and glaucoma; were published as of July 20, 2016; and included at least 1 trial and the trials included in the reviews. For each disease, a pair of clinical experts independently classified al2017-01-01T00:00:00Z2017 Sep2025-05-29T22:09:55.737Z2019-03-26T23:55:31ZS-EPMC56253422877230510.1001/jamaophthalmol.2017.2583