biostudies-literatureNuno MMNIA NIH HHSNational Institute on Aging81https://www.ebi.ac.uk/biostudies/studies/S-EPMC5628443biostudies-literatureUnknown9(1)<h4>Background</h4>Research has revealed that manifest Alzheimer's disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology is accumulating but function remains intact. This understanding and concern that disease-modifying interventions initiated at the dementia stage may come too late in the neurodegenerative process to be successful has led to a paradigm shift in AD clinical trials. AD trials now enroll patients with mild cognitive impairment (MCI) and persons with no cognitive symptoms. Trial designs are similar to those enrolling dementia participants. We set out to test the hypothesis that attitudes towards trial design features differ among different potential AD trial populations.<h4>Methods</h4>We sent a survey composed of 37 items assessing specAlzheimer's research & therapyAttitudes toward clinical trials across the Alzheimer's disease spectrum.PMC5628443AG AG016573AG016570P50 AG016573P50 AG016570Dosanjh KKNuno MMBrook JGrill JDGillen DLElashoff DRingman JMfalseAttitudes toward clinical trials across the Alzheimer's disease spectrum.<h4>Background</h4>Research has revealed that manifest Alzheimer's disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology is accumulating but function remains intact. This understanding and concern that disease-modifying interventions initiated at the dementia stage may come too late in the neurodegenerative process to be successful has led to a paradigm shift in AD clinical trials. AD trials now enroll patients with mild cognitive impairment (MCI) and persons with no cognitive symptoms. Trial designs are similar to those enrolling dementia participants. We set out to test the hypothesis that attitudes towards trial design features differ among different potential AD trial populations.<h4>Methods</h4>We sent a survey composed of 37 items assessing spec2017-01-01T00:00:00Z2017 Oct2026-07-15T21:23:03.436Z2026-07-09T10:13:39.215ZS-EPMC56284432897833510.1186/s13195-017-0311-5