{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(39)"],"submitter":["Huang F"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Chronic hepatitis B virus (HBV) infection is a major cause for HCC. Hepatitis B virus X (HBx), one of four proteins encoded by HBV genome, plays a vital role in the pathogenesis of HBV-induced HCC. However, the molecular mechanisms of HBx-triggered HCC remain largely undetermined. Here we revealed that the expression of Brain-expressed X-linked 2 (BEX2) and Osteopontin (OPN) were elevated in liver tissues of HBV transgenic mice and human HCC specimens. Moreover, a positive correlation between BEX2 and OPN was exhibited in samples from HCC patients with HBV infection. The protein levels of BEX2 and OPN were both higher in HBV-positive HCC specimens compared to that of HBV-negative HCC specimens. HBx"],"journal":["Oncotarget"],"pagination":["65789-65799"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5630372"],"repository":["biostudies-literature"],"pubmed_title":["Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development."],"pmcid":["PMC5630372"],"pubmed_authors":["Huang F","Hu Z","Cai P","Liao W","Zhang H","Chen H","Wang Y","Zhou X","Mao Y","Zha X"],"additional_accession":[]},"is_claimable":false,"name":"Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development.","description":"Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Chronic hepatitis B virus (HBV) infection is a major cause for HCC. Hepatitis B virus X (HBx), one of four proteins encoded by HBV genome, plays a vital role in the pathogenesis of HBV-induced HCC. However, the molecular mechanisms of HBx-triggered HCC remain largely undetermined. Here we revealed that the expression of Brain-expressed X-linked 2 (BEX2) and Osteopontin (OPN) were elevated in liver tissues of HBV transgenic mice and human HCC specimens. Moreover, a positive correlation between BEX2 and OPN was exhibited in samples from HCC patients with HBV infection. The protein levels of BEX2 and OPN were both higher in HBV-positive HCC specimens compared to that of HBV-negative HCC specimens. HBx","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-04-22T05:52:40.603Z","creation":"2021-02-21T03:07:46Z"},"accession":"S-EPMC5630372","cross_references":{"pubmed":["29029472"],"doi":["10.18632/oncotarget.19477"]}}