biostudies-literature00500Alexy EJNIGMS NIH HHS5007-5009https://www.ebi.ac.uk/biostudies/studies/S-EPMC5632216biostudies-literatureUnknown19(19)A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The ?-quaternary 4-thiopyranones produced are challenging to access by standard enolate alkylation owing to facile ring-opening ?-sulfur elimination. In addition, reduction of the carbon-sulfur bonds provides access to elusive acyclic ?-quaternary ketones. The alkylated products are obtained in up to 92% yield and 94% enantiomeric excess.Organic lettersEnantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic ?-Quaternary Ketones.PMC5632216R01 GM080269Alexy EJStoltz BMBartberger MDVirgil SC50falseEnantioselective Pd-Catalyzed Decarboxylative Allylic Alkylation of Thiopyranones. Access to Acyclic, Stereogenic ?-Quaternary Ketones.A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The ?-quaternary 4-thiopyranones produced are challenging to access by standard enolate alkylation owing to facile ring-opening ?-sulfur elimination. In addition, reduction of the carbon-sulfur bonds provides access to elusive acyclic ?-quaternary ketones. The alkylated products are obtained in up to 92% yield and 94% enantiomeric excess.2017-01-01T00:00:00Z2017 Oct2020-10-31T08:57:37Z2019-03-26T23:57:58ZS-EPMC56322162890176910.1021/acs.orglett.7b02354