{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou PJ"],"funding":["Shanghai Jiaotong University Foundation for Medicine-Engineering Science Project","Science and Technology Commission of Shanghai Municipality","KC Wong foundation","Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China","Natural Science Foundation of Shanghai City","“ChenGuang Project” of Shanghai Education Committee and Shanghai Education Development Foundation 2013"],"pagination":["139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5633884"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(1)"],"pubmed_abstract":["Background
Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic cancer. Although loss or dislocalization of polarity proteins has been implicated in embryogenesis deficiency and tumorigenesis, association of polarity protein expression levels with tumor metastasis remains unclear.Methods
Bioinformatics, qRT-PCR, western blot and immunohistochemical (IHC) analyses were used to examine expression of Par3, a key component of polarity-associated partitioning defective (PAR) complex, in primary and metastatic clinical PCa samples. Loss-of-function and gain-of-function studies in vitro and in vivo were performed to determine the f"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway."],"pmcid":["PMC5633884"],"funding_grant_id":["13CG15","2017YFA0102900","16JC1405700","81372189","81130038","15ZR1422700","81301857","81672543","YG2012MS47","31401233"],"pubmed_authors":["Xue W","Yang Z","Gao WQ","Zhu HH","Zhou PJ","Wang Y","Fang YX","Peng J","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.","description":"Background
Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic cancer. Although loss or dislocalization of polarity proteins has been implicated in embryogenesis deficiency and tumorigenesis, association of polarity protein expression levels with tumor metastasis remains unclear.Methods
Bioinformatics, qRT-PCR, western blot and immunohistochemical (IHC) analyses were used to examine expression of Par3, a key component of polarity-associated partitioning defective (PAR) complex, in primary and metastatic clinical PCa samples. Loss-of-function and gain-of-function studies in vitro and in vivo were performed to determine the f","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-27T03:54:53.431Z","creation":"2019-03-27T02:58:32Z"},"accession":"S-EPMC5633884","cross_references":{"pubmed":["29017577"],"doi":["10.1186/s13046-017-0609-y"]}}