{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clark CN"],"funding":["Wolfson Foundation","Alzheimer's Society","NIHR Rare Disease Translational Research Collaboration","NIHR Queen Square Dementia Biomedical Research Unit","Alzheimer's Research UK","National Brain Appeal – Frontotemporal Dementia Research Fund","Medical Research Council","MRC Clinician Scientist Fellowship","National Institute for Health Research (NIHR)","Brain Research Trust","Alzheimer's Society","Wellcome Trust Senior Clinical Fellowship","Wellcome Trust"],"pagination":["144-156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5637159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104"],"pubmed_abstract":["Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n = 19) and semantic dementia (SD; n = 10) relative to healthy older individuals (n = 20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional c"],"journal":["Neuropsychologia"],"pubmed_title":["Auditory conflict and congruence in frontotemporal dementia."],"pmcid":["PMC5637159"],"funding_grant_id":["MR/M023664/1","AS","MR/M008525/1","CL-2012-18-010","16","MR/J009482/1","PG","007","1332624","AS-PG-16-007","091673/Z/10/Z"],"pubmed_authors":["Russell LL","Brotherhood EV","Warren JD","Rohrer JD","Clark CN","Agustus JL","Nicholas JM","Dick KM","Marshall CR","Hardy CJD","Mummery CJ"],"additional_accession":[]},"is_claimable":false,"name":"Auditory conflict and congruence in frontotemporal dementia.","description":"Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n = 19) and semantic dementia (SD; n = 10) relative to healthy older individuals (n = 20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional c","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2025-04-26T20:05:10.464Z","creation":"2019-03-27T02:58:43Z"},"accession":"S-EPMC5637159","cross_references":{"pubmed":["28811257"],"doi":["10.1016/j.neuropsychologia.2017.08.009"]}}