biostudies-literatureClark CNWolfson FoundationAlzheimer's SocietyNIHR Rare Disease Translational Research CollaborationNIHR Queen Square Dementia Biomedical Research UnitAlzheimer's Research UKNational Brain Appeal – Frontotemporal Dementia Research FundMedical Research CouncilMRC Clinician Scientist FellowshipNational Institute for Health Research (NIHR)Brain Research TrustAlzheimer's SocietyWellcome Trust Senior Clinical FellowshipWellcome Trust144-156https://www.ebi.ac.uk/biostudies/studies/S-EPMC5637159biostudies-literatureUnknown104Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n = 19) and semantic dementia (SD; n = 10) relative to healthy older individuals (n = 20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional cNeuropsychologiaAuditory conflict and congruence in frontotemporal dementia.PMC5637159MR/M023664/1ASMR/M008525/1CL-2012-18-01016MR/J009482/1PG0071332624AS-PG-16-007091673/Z/10/ZRussell LLBrotherhood EVWarren JDRohrer JDClark CNAgustus JLNicholas JMDick KMMarshall CRHardy CJDMummery CJfalseAuditory conflict and congruence in frontotemporal dementia.Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n = 19) and semantic dementia (SD; n = 10) relative to healthy older individuals (n = 20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional c2017-01-01T00:00:00Z2017 Sep2025-04-26T20:05:10.464Z2019-03-27T02:58:43ZS-EPMC56371592881125710.1016/j.neuropsychologia.2017.08.009