biostudies-literatureHoltrup BNIGMS NIH HHS224-233https://www.ebi.ac.uk/biostudies/studies/S-EPMC5638358biostudies-literatureUnknown6(3)Over the past 2 decades, the incidence of childhood obesity has risen dramatically. This recent rise in childhood obesity is particularly concerning as adults who were obese during childhood develop type II diabetes that is intractable to current forms of treatment compared with individuals who develop obesity in adulthood. While the mechanisms responsible for the exacerbated diabetic phenotype associated with childhood obesity is not clear, it is well known that childhood is an important time period for the establishment of normal white adipose tissue in humans. This association suggests that exposure to obesogenic stimuli during adipose development may have detrimental effects on adipose function and metabolic homeostasis. In this study, we identify the period of development associated wAdipocytePuberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis.PMC5638358T32 GM007223T32 GM007499Rodeheffer MSHoltrup BBober JBerry RJeffery EChurch CDColman LfalsePuberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis.Over the past 2 decades, the incidence of childhood obesity has risen dramatically. This recent rise in childhood obesity is particularly concerning as adults who were obese during childhood develop type II diabetes that is intractable to current forms of treatment compared with individuals who develop obesity in adulthood. While the mechanisms responsible for the exacerbated diabetic phenotype associated with childhood obesity is not clear, it is well known that childhood is an important time period for the establishment of normal white adipose tissue in humans. This association suggests that exposure to obesogenic stimuli during adipose development may have detrimental effects on adipose function and metabolic homeostasis. In this study, we identify the period of development associated w2017-01-01T00:00:00Z2017 Jul2025-04-04T21:22:15.164Z2019-03-26T23:49:38ZS-EPMC56383582879278510.1080/21623945.2017.1349042