{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Yamamotoya T"],"pubmed_abstract":["The Trk-fused gene (TFG) is reportedly involved in the process of COPII-mediated vesicle transport and missense mutations in TFG cause several neurodegenerative diseases including hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). The high coincidence ratio between HMSN-P and diabetes mellitus suggests TFG to have an important role(s) in glucose homeostasis. To examine this possibility, β-cell specific TFG knockout mice (βTFG KO) were generated. Interestingly, βTFG KO displayed marked glucose intolerance with reduced insulin secretion. Immunohistochemical analysis revealed smaller β-cell masses in βTFG KO than in controls, likely attributable to diminished β-cell proliferation. Consistently, β-cell expansion in response to a high-fat, high-sucrose (HFHS) d"],"journal":["Scientific reports"],"pagination":["13026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5638802"],"repository":["biostudies-literature"],"pubmed_title":["Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity."],"pmcid":["PMC5638802"],"pubmed_authors":["Ishihara H","Nakatsu Y","Inoue MK","Sakoda H","Yamamotoya T","Ueda K","Matsunaga Y","Ono H","Asano T","Kushiyama A","Fujishiro M","Inoue Y","Kiyonari H"],"additional_accession":[]},"is_claimable":false,"name":"Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.","description":"The Trk-fused gene (TFG) is reportedly involved in the process of COPII-mediated vesicle transport and missense mutations in TFG cause several neurodegenerative diseases including hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). The high coincidence ratio between HMSN-P and diabetes mellitus suggests TFG to have an important role(s) in glucose homeostasis. To examine this possibility, β-cell specific TFG knockout mice (βTFG KO) were generated. Interestingly, βTFG KO displayed marked glucose intolerance with reduced insulin secretion. Immunohistochemical analysis revealed smaller β-cell masses in βTFG KO than in controls, likely attributable to diminished β-cell proliferation. Consistently, β-cell expansion in response to a high-fat, high-sucrose (HFHS) d","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-04T21:22:22.363Z","creation":"2019-03-27T02:58:49Z"},"accession":"S-EPMC5638802","cross_references":{"pubmed":["29026155"],"doi":["10.1038/s41598-017-13432-x"]}}